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KMID : 0870420140180040152
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Korean Journal of Hepato-Biliary-Pancreatic Surgery
2014 Volume.18 No. 4 p.152 ~ p.158
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Surgical outcomes of multifocal branch duct intraductal papillary mucinous neoplasms of pancreas
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Kwon Jae-Hyun
Kim Song-Cheol
Song Ki-Byung
Lee Jae-Hoon
Hwang Dae-Wook
Park Kwang-Min
Lee Young-Joo
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Abstract
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Background/Aims: Appropriate management for multifocal branch duct type intraductal papillary mucinous neoplasms (BD-IPMNs) of the pancreas is still controversial. This study was intended to reveal surgical outcomes of surgical re-section for multifocal BD-IPMNs, with BD-IPMNs in the remnant pancreas.
Methods: Between January 1995 and December 2013, 699 patients underwent the pancreatic resection due to IPMN of pancreas in our institution. Among them, 37 patients showed multifocal BD-IPMNs. After excluding patients who had BD-IPMNs completely resected, medi-cal records of 22 patients with remained BD-IPMNs in the remnant pancreas were retrospectively reviewed.
Results: Mean patient age was 65±6.4 years. Types of surgery included central pancreatectomy (n=1), distal pancreatectomy (n=14), and standard pylorus-preserving pancreaticoduodenectomy (n=7). Specimen pathology showed that IPMN was either at low/intermediate-grade dysplasia (n=17) or at high-grade dysplasia (n=2). Three patients had IPMN associated with invasive carcinoma. Their mean follow-up period was 40.4 months. During follow-up, one mortality occurred 35.2 months after the operation which was not associated with IPMN. There was no clinically significant disease progression or recurrence of IPMN in the remnant pancreas during the follow-up period.
Conclusions: Our results support that we can safely preserve the pancreas parenchyma with multifocal BD-IPMNs. Benign-looking multifocal BD-IPMNs in the remnant pancreas do not affect the survival of patients. (Korean J Hepatobiliary Pancreat Surg 2014;18:152-158)
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KEYWORD
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Pancreatectomy, Intraductal papillary mucinous neoplasms, Branch duct, Multifocal, Follow-up
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